| Association with Fasting Blood Insulin Concentration and Cardiovascular Risk Factor Disease in Prediabetic Adults. |
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Mun-Gi Choi, Jin-Hong Kim |
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Inha University |
Correspondence:
Jin-Hong Kim,
Email: smedizin@inje.ac.kr
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Received: 1 December 2014 • Accepted: 14 February 2015 |
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| Abstract |
PURPOSE
The purpose of our study was to determine whether cardiovascular risk factor disease and cytokine are associated with fasting blood insulin concentration in prediabetic adults. We also examined the protective target for metabolic disease, diabetes and cardiovascular disease in prediabetic adults with insulin resistance.
METHODS
Fifty healthy male and female university students were randomly assigned and divided into four groups[ > 5μIU/mL(n=9), 5-10μIU/mL(n=26), 10-15μIU/mL(n=7), < 15μIU/mL(n=8)].
RESULTS
There was were significantly differences such as body fat mass(p<.05), %fat mass(p<.05), waist circumference(p<.001), HDL-C(p<.05), insulin(p<.001), PAI-1(p<.05) between groups. The effect between time and groups showed a significant difference in insulin(p<.05), HOMA-IR(p<.05). Significant positive correlation was observed between weight(r=.312), fat mass(r=.389), BMI(r=.322), waist circumference(r=.415), Glucose(r=.301), HOMA-IR(r=.998) and PAI-1(r=.045).
CONCLUSIONS
Our results showed that higher fasting insulin concentration was contributed to cardiovascular disease and diabetes. These results demonstrated that regulation of insulin resistance and inflammatory cytokines may be a beneficial therapeutic targets for preventing cardiovascular disease and diabetes. |
| Keywords:
fasting insulin, cardiovascular predictor, homeostasis model assessment, cytokine |
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